The most-read content from the 2023 American Society of Hematology Annual Meeting and Exposition included the latest in treating hematologic malignancies, the hope brought by novel therapy strategies, and the potential for artificial intelligence to improve diagnostic accuracy.
The most-read content from the 2023 American Society of Hematology Annual Meeting and Exposition included the latest in treating hematologic malignancies, the hope brought by novel therapy strategies, and the potential for artificial intelligence (AI) to improve diagnostic accuracy.
Check out the rest of our ASH 2023 coverage here.
5. Is Genome Editing the Next Step in Immunotherapy Innovation? Experts Think So
In recent years, chimeric antigen receptor (CAR) T-cell therapies have brought hope to patients with certain hematologic cancers that previously had few, if any, effective treatment options. In a presentation at ASH 2023, experts in the field expressed optimism that CAR T-cell therapy is just the beginning of what can be done with cellular immunotherapy. With technologies such as CRISPR genome editing carrying potential to improve immunotherapy efficacy, the hope is that ongoing research will translate to clinical utility in the near future.
4.Cellular Therapies in Lymphoma Bring Hope, but Optimizing Their Use Remains a Challenge
Cellular therapies such as CAR T-cell therapies have changed the landscape of hematologic cancer treatment in recent years, but a roster of experts at ASH 2023 noted that the best way to use and sequence these therapies is still not entirely understood. Identifying prognostic factors for cellular therapy response, determining the role of bridging therapy, and managing aggressive lymphomas following CAR T-cell therapy failure were key questions discussed by presenters.
3.Results Show Strong Responses for Brentuximab Vedotin Plus Nivolumab Combo in Patients With cHL
Data from 2 abstracts at ASH 2023 demonstrated promising responses among patients treated with brentuximab vedotin plus nivolumab in a 4-drug regimen for classical Hodgkin lymphoma (cHL). Results showed 100% of patients with early-stage cHL were still progression-free at 12 months. Among those with advanced disease, 88% remained progression-free at 24 months.
2. Dr Andrew Srisuwananukorn on the Potential for AI in Differentiating prePMF and ET
AI has emerged as a potentially useful tool across numerous clinical tasks, and an abstract presented at ASH 2023 showed an algorithm capable of differentiating between primary myelofibrosis (prePMF) and essential thrombocythemia (ET) with 92.3% accuracy. AI-based decision support tools may be especially helpful for clinicians who do not see prePMF or ET frequently, lead author Andrew Srisuwananukorn, MD, of Ohio State University Comprehensive Cancer Center, told The American Journal of Managed Care® in this video interview.
1. ALPINE: After 39 Months, Zanubrutinib Keeps Its PFS Edge Over Ibrutinib in R/R CLL, Especially for High-Risk Patients
At 39 months of follow-up, zanubrutinib demonstrated a 32% improvement in progression-free survival compared with ibrutinib in patients with for chronic lymphocytic leukemia (CLL) or small lymphocytic leukemia after 1 prior line of treatment, according to findings from the phase 3 ALPINE trial presented at ASH 2023. During the presentation, Jennifer Brown, MD, PhD, of Dana-Farber Cancer Institute, explained that zanubrutinib has higher concentration ratios and thus offers more complete inhibition of BTK compared with ibrutinib, and that it produces fewer off-target effects.
Real-World Data Show Sotorasib Effective for NSCLC With KRAS Mutation
May 18th 2024Data from real-world and clinical-trial settings on frontline monotherapy treatment with the KRAS inhibitor sotorasib both show similar progression-free survivals and a high likelihood that the treatment’s efficacy is not affected with dose reduction.
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CMS Medicare Final Rule: Advancing Benefits, Competition, and Consumer Protection
May 7th 2024On this episode of Managed Care Cast, we're talking with Karen Iapoce, senior director of government products and programs at ZeOmega, about the recent CMS final rule on Medicare Part D and Medicare Advantage.
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Study Highlights Significant Increases in Utilization, Spending on DMD Drugs in Medicaid
May 17th 2024The findings add to recent research on the growing utilization, expenditure, and prices of Duchenne muscular dystrophy (DMD) therapies in the current landscape, an area health care policy could potentially address.
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Perioperative Nivolumab Boosts NSCLC Survival: CheckMate 77T Trial
May 16th 2024This interim analysis of the CheckMate 77T trial, outcomes were compared between adult patients receiving neoadjuvant nivolumab plus chemotherapy or neoadjuvant chemotherapy plus placebo for resectable non–small cell lung cancer (NSCLC).
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ATS 2024: Bridging the Past, Present, and Future of Respiratory Care
May 16th 2024The application of artificial intelligence in medicine is anticipated as a highlight of ATS 2024, with sessions exploring its applications in research, radiological interpretation, and pediatric pulmonology.
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